Connect with us

Research

Hepatotoxin and Liver Damage – The Side Effects of CBD

Published

on

CBD Side Effects Liver Damage

In physics, the formula of Momentum is Mass multiplied by Velocity. If that’s the case, then the CBD Bandwagon is gaining momentum, day by day.  The rate at which people and nations are accepting its use and production propagates its velocity. The increasing popularity of the substance is leading more and more people and organizations to get on the CBD Bandwagon, increasing its support and mass. Combined, its slowly turning into an unstoppable force.

But what happens when that unstoppable force meets an immovable object? Nerdy physics and sagacious philosophies aside, its side-effects might just be the immovable object that it collides into. According to the Molecules Journal, Volume 24, Issue 9, CBD is not as harmless as its supporters make it out to be.

The Role of CBD in Medicine

But why do people use CBD in the first place? For starters, it’s the substance found in Cannabis that is non-addictive (THC is the addictive part). So, naturally, the belief that goes with that, makes it a lot less harmful than THC. Given its pain relieving and sleep-inducing properties, it provides the same effects with a lot fewer side-effects than its alternatives (like opium).

When we say “a lot less harmful” we mean “a lot less harmful” and not “harmless”, as most of its supporters are believing it to be. Sure, it has its own benefits not only with its restorative properties but also in its effectiveness in suppressing epileptic symptoms, as evidenced by the studies conducted by Devinsky and Sanjay Gupta. But that does not warrant a full green light for this product’s side-effects.

Cannabidiol’s Side Effects on the Liver

According to the study conducted for the Journal, the effects on the hepatotoxicity on 8-week-old mice have been observed. All the specimens were males and different groups have been tested with different dosage of CBD. These dosages were calculated and administered according to the mice’s bodies, meaning, the dosage administered for human subjects were scaled down to match the requirements of a mouse’s body.

The results showed a stunning 75% of the test subjects with a dosage above 615 mg/KG, showing signs of damaged liver, including increased bilirubin, LBW Ratios, AST and ALTs in just one day. The CBD definitely displayed some hepatotoxic behavior, but the Journal concludes it to be of a cholestatic nature, with a hint of “maybe”. While there have been a “maybe” on its nature, there was no doubt about its hepatotoxicity.

The Proper Use of CBD

With all the research going on, and the benefits of CBD being so clear, it’s hard to just stop right here and move on without using it. Now that the benefits of CBD have been widely accepted by the medical community, it’s time to look into its proper use with calculated doses. Because, to be honest, no modern medication comes without its own sets of side-effects anyway.

But if the studies were any indication of how CBD is going to react with human bodies, then we should remain well under the daily limit of 20 mg/KG dosage. In all honesty, even if we maintained that limit, we’d still be well below the 615 mg/KG dosage that resulted in the liver damage of the mouse subjects. That obviously doesn’t mean that 20 mg/KG is safe either since 615 mg/KG caused the damage in a day and lower doses might cause the same damage through long-term use. But if CBD is taken with proper care and in the right amounts, you could reap its benefits without its negative effects.

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Research

Marijuana Concentrate: What it is and why teens use it

Published

on

Marijuana Concentrate What it is and why teens use it

A new study reveals that more teens are now using the more potent form of cannabis, which is marijuana concentrate. The research published recently also stated that said teens are likely to use and abuse different substances, too.

Marijuana concentrates are significantly more potent in that it contains really high amounts of tetrahydrocannabinol or THC, the component responsible for the psychoactive properties of marijuana. The concentrate may contain 40-80% (and higher in some cases) of THC in some of the products.

In contrast, the THC amount in a high-grade cannabis plant only averages about 20%.

The Arizona Youth Survey

The study published in August in the pages of the Pediatrics journal is the collated data from teens in the eighth, tenth and twelfth grade in the state, and amounted to almost 50,000 students in all. This study is based on the results gathered in the Arizona Youth Survey.

The research revealed that 33% of the participating students have tried cannabis once or more. Also, 24% owned up to having used marijuana concentrates at one time or another.

The concentrate is often called honey oil or budder due to its honey or butter-like appearance. It is also called by other names like dabs, hash oil, butane honey oil or BHO and 710.

The marijuana concentrate can be mixed to drinks or food, and even smoked using oil pipes or water. Other people like to use a vaporizer or an e-cigarette to inhale the vaporized form of the concentrate.

Among the participants, the 12th graders had a high number of users at 32.9%. Girls had a higher occurrence, and as well as students having parents who weren’t able to finish their high school.

The study also showed that students who use marijuana concentrates are more likely to get ahold of other substances, specifically e-cigarettes, as compared to users who consume other cannabis forms.

The researches further note how the number of students using this form of marijuana might be risking themselves of drug abuse since past studies show that adults exposed to high THC amounts are likely to suffer from cannabis use disorder, psychosis, and cognitive impairment.

UCI Center for the Study of Cannabis director at University of California Daniele Piomelli, Ph.D., PharmD, states that there is no clear reason why many teens use marijuana concentrates. Past trends from the 70s to the 90s only showed people using low THC-containing cannabis.

Concentrate dosage differs the effect

Plant cannabis use is a lot less potent than the concentrate, which means that using stronger marijuana concentrate can also produce greater psychological and physical differences in the user. However, the gravity of the effect will still depend on how much a person uses a substance, which in this case is marijuana.

Assistant professor at Colorado State University Mark Prince, Ph.D., stated that the research shows how frequent and heavy use of cannabis can definitely cause deleterious effects. However, he also adds that not having enough scientific information blurs the line between beneficial and dangerous cannabis use.

Marijuana concentrates the long-term effect

Piomelli stated that there is next to no information about the effects of dabbing or vaping products using marijuana concentrate. This leads experts to believe that the long-term effects of such preparation are still largely unknown.

Lab tests done by Prince and his team looked into cannabis potency and its effect on physical and mental effects but results have been mixed so far.

Field experts are convinced that more research needs to be conducted to determine all its effects, whether long or short term. There is still little to no knowledge about the chronic effect of the said substance.

Continue Reading

Research

Millennials are Preferring CBD Oil Treatments

Published

on

Milennials Are Preferring CBD Oil

The CBD Bandwagon has rolled too far to be pushed back into oblivion: or that’s what the recent studies believe. According to the study conducted by the NHS, about 50% of the millennials prefer to use CBD oil over prescription medicine any day. But what does that truly mean for the CBD Market? And why is it so important in the modern day world?

The Study

The National Health Services of England (NHS for short), has been funding different research behind providing better medical services to the patients. Recently, they had commissioned a study on 2000 adult subjects in the United Kingdom, in order to find the number of health-conscious millennials who are preferring to turn towards Cannabidiol oil as medication.

According to the studies, around 30% of the Britons are careful about going to psychiatrists for their mental ailments in the fear of being prescribed medicine that might be overkill for their symptoms; leaving them with severe side-effects and medicine dependencies. 38% of them are leaning towards CBD Oil for treating their symptoms, while 24% of the subjects prefer other holistic methods of treatment. Interestingly, if we separated these subjects with respect to their age, we can see that almost 50% of the millennials in the UK prefer to use CBD as a treatment for their mental ailments.

CBD Benefits

We have already spoken about the benefits of CBD countless times on our website. But for the newer readers among you, a slight recap might be in order for you to understand why so many people are leaning towards it nowadays. First of all, CBD is the component of Cannabis that isn’t addictive. This is a big deal as it helps its user to ensure that he or she will not become dependent on this medicine once he or she starts using it.

Second, it has many reported benefits in the beauty industry, the medical industry as well as in the world of psychiatry. In terms of beauty, its topical use can provide smoother skin, reduce dryness, reduce acne breakouts and ease skin irritation. As for its medicinal properties, it is a great pain reliever and can be considered as an alternative to a lot of other addictive painkillers such as opium.

It works great as a stress-reliever, anxiety reducer and sleeps inducer. But its most prominent use would most likely be the properties that make it suitable to be used as a medication for controlling epileptic seizures. With little to no side-effects, the benefits of CBD is huge.

How it affects the Market

After seeing such a rise in its popularity among different age groups, it’s no surprise that CBD can have a great impact on the market. According to different estimates, the CBD might hold a 17 Billion USD market in the world for beauty treatments and over 20 Billion in combined markets, by the year 2024. With such prospects dangling in the horizon, it’ll hardly come as a surprise if this research incites the British Government to relax some of their laws concerning this substance.

Continue Reading

Research

CBD Helps Pets Calm Down During Firework Stress

Published

on

CBD Pets Stress

Fourth of July noise

We all love a loud celebration. But our pets? Not so much. With the Fourth Of July upon us, many pet owners are turning to products that can help keep their pets calm during the explosive celebration. Many of the newer products in this category contain the active ingredient cannabidiol or CBD.

Stormy may be an ironic name for a dog because her name definitely doesn’t suit her dislike for loud noises. According to her owner, Hanbee Choi, Stormy is not a fan of loud noises like the vacuum, and of course, fireworks and firecrackers aren’t an exception. She also said that Stormy would hide under places whenever she’d hear the loud noises.

CBD helps pets calm down

Choi dropped by Chuck and Don’s pet store to look for products that will help with her pet’s stress and anxiety. She looked for products that contain the specific ingredient of cannabidiol or CBD. It’s a product derived from hemp that’s a powerful supplement. This particular compound is famous for its many health benefits without the intense side effects.

Elizabeth Hayden, the pet supplies store’s assistant manager says that CBD can cure diseases like a seizure, and also help alleviate pain, anxiety, stress, inflammation, etc. More customers are going for any CBD products in the form of a chewable tablet or gummies or concentrated oils. These CBD products are not like prescription drugs from veterinarians wherein you have to slowly wean off pets from it. They can be given to pets as needed, without the need to gradually decrease the dose as with the usual drugs given by vets.

Choi shares that CBD helps keep her dogs calm during car rides. She said that with CBD oil, her dog wouldn’t throw up or have any stomach issues during car rides. It kept the dog calm, allowing him to law down and go to sleep.

Keeping your pets calm during the noise

Staff recommends still placing pets in a quiet place on the Fourth of July or any day where you would anticipate fireworks. CBD-containing products should only be used in conjunction with that. You can place your pets away from windows or open spaces and play some music to drown out the noise.

The staff of the pet store supplies suggests that pet owners consult with their vets first before trying out any CBD products especially if they are also taking other drugs that may interfere with it. However, pet owners shouldn’t worry much about the side effects when using CBD on their pets. Many studies have proven the health benefits of CBD on pets as well as its safety even when taken at high doses or just occasional use.

Ultimately, CBD can be a life-saving supplement for your pets. It has significant calming effects on your pets that you will surely appreciate during times of stress like firework season

Continue Reading

Trending