A Marin County medical cannabis and pharmaceutical coalition says it’s discovered a way to ramp up production of a few of those rarest compounds made by marijuana blossoms that ancient studies demonstrate could be a means to take care of diabetes, reduced cholesterol and offer additional health benefits.
This cannabinoid called THCV, or tetrahydrocannabivarin, is regarded as among the rarest cannabinoids and can be only found in trace quantities in many breeds of this plant.
Dr. Michael Moskowitz, of San Rafael, president of the Bay Area Pain Medical Associates along with a local psychologist, is the creator of the Medical Cannabis Research Consortium of Marin, that was analyzing THCV. He started recommending medical cannabis to patients in 2015 and discovered it had several abstract advantages, such as individuals decreasing psychiatric and psychiatric pain medication usage.
He said he plans to examine THCV’s consequences on a single individual that has been severely influenced by both childhood and adult type II diabetes.
“The one thing which THCV does is it is analgesic and anti inflammatory, it is neuroprotective, so it protects the nervous system,” Moskowitz said. “It is anti-nausea and nausea. It assists with bone health and bone formation, so it is sleep-promoting, it is anti-epileptic, it is anti-anxiety. It is a significant anti-psychotic. Plus it will help with appetite suppression, it is anti-diabetic and it is anti-cholesterol.
“Apart from that it did not do so much,” Moskowitz joked.
Moskowitz explained that despite its rarity, THCV isn’t regarded as a risky medication, has no lethal dose also contains insignificant side effects.
“The remedy for the negative effects is really a rest,” he explained.
The Bel Marin Keys-based bio-pharmaceutical firm Liposome Formulations Inc., that can be a part of the local consortium, announced this week it will be releasing many new medical cannabis products, among which will be a THCV tablet computer.
Bill Heriot, the corporation’s manufacturing director, stated the liposome patents that they hold permits for quicker absorption of drugs and dietary supplements work for medical cannabis too. The business is also undergoing clinical trials using the Food and Drug Administration for a medication which treats osteoarthritis.
The business is hosting an open house on Friday in 42 Digital Drive, Suite 6, in Novato for the Novato City Council, city staff and the people as the city starts work to develop cannabis industry regulations.
Heriot reported the objective of the consortium is to produce a vertically-integrated medical cannabis firm — meaning controllers from generation through sale — which are going to have the ability to provide medical grade cannabis products for patients.
“We aim to compete directly with GW Pharmaceuticals since we’ve got the patents, the engineering and the know-how to do precisely that, which is indicative of,” Heriot explained. “We are a little, privately-owned business and can proceed very quickly and pivot on a dime to put in this market, which is exactly what our aim is actually doing. It is exciting times ahead.”
Researchers such as Heriot, Moskowitz and many others from the consortium are optimistic that THCV may go the way of another cannabinoid known generally as CBD, cannabidiol, in the health care world.
Back in June, the U.S. Food and Drug Administration’s accepted a cannabis-based epilepsy medication Epidiolex, which medical cannabis supporters are expecting is signaling a prospective change in tolerance for cannabis’ pharmaceutical applications.
GW Pharmaceuticals, the company that produced Epidiolex, has also been exploring THCV as possible treatment for a number of ailments and wellness problems such type II diabetes, schizophrenia, epilepsy, cognitive disorders like Alzheimer’s, together with various others.
There’s been a peer-reviewed study conducted on the consequences of THCV, largely beyond the U.S., which discovered it to be promising for diabetes therapy.
A 2013 research in Nature’s Nutrition and Diabetes journal analyzed THCV on mice and reasoned that it might be a possible cure for type II diabetes. The research was partially funded by GW Pharmaceuticals and a few of the analysis coauthors were employees or stockholders in the organization.
More lately, a 2016 Diabetes Care journal also reasoned THCV might represent a new therapeutic agent blood glucose control for individuals with type II diabetes. A 2012 research in the American Journal of Pathology said that THCV appears to be a”promising therapeutic chemical” for treating diabetes by reducing inflammation and oxidative stress, and also the analysis says”are crucial processes in the evolution of diabetes and diabetic complications.”
As to if THCV can also be psychoactive like THC, Moskowitz stated it’s been categorized as equally, but stated the study to support either decision is lacking.
Longtime Marin County resident George Bianchini, creator of the medical cannabis firm Medi-Cone, said he inadvertently stumbled upon the breed of cannabis that generates large levels of THCV.
He discovered the breed that afterwards was called”Black Beauty” a long time back when he and a study partner, Ed Rosenthal, were mutating the genotypes of this plant. They had been hoping to fortify the plant fragrance-producing terpenes so it might be marketable, but what they got was something much different.
Bianchini said he almost chucked the strain after laboratory test results revealed it had reduced THC without a CBD. Prior to doing this, he said that he got a call in Steep Hill Labs at Oakland notifying him that the breed was generating a remarkably large proportion of THCV — roughly 3.5 percent.
“I said,’You know I needed to ask you about that. What can it be?'” Bianchini said. “I’ve been in this sector for some time and hadn’t ever heard of it”
These greater THCV levels are thought to have originated in breeds by sub-Saharan Africa, based Bianchini and Moskowitz. However, as cannabis became lucrative from the 20th century, particularly those with higher THC levels, Bianchini said growers were breeding their crops to produce more THC in the price of different cannabinoids.
“What we have been doing is switching that via breeding and that is the very first one that we have come up with,” Bianchini said. “Now we have gone from a single and we have developed four different phenotypes.”
But despite the high THC levels, the price to create enough cannabis to generate THCV production marketable remains fairly high, particularly considering California’s regulations.
Bianchini said he is currently focusing his attention on hemp, also stated they’ve almost bred this large THCV-producing genetic information to a lawful industrial hemp plant. This may significantly decrease the expense of generation for THCV since Congress believes the 2018 Farm Bill, that could effectively legalize hemp, even though there’s still question about if it would nevertheless be categorized as berry.
The Marin-based medical cannabis consortium stated the ultimate aim is to receive a federally-approved pharmaceutical medication containing THCV. By having a certified pharmaceutical business via Liposome Formulations on its own side, Bianchini said they have got a leg up.
“Regardless of who’s creating a health solution, it is going to need to be via a FDA-licensed pharmaceutical company,” Bianchini said.
Pregnant women and lactating mothers should keep away from Marijuana and CBD warns the FDA
The FDA has strictly warned people against the usage of marijuana or products containing CBD or cannabidiol especially when one is pregnant or is breastfeeding. In the USA, the popularity of CBD products has swerved a new high with 1 in 7 people ingesting products containing CBD. This study conducted by Gallup on adults is proof of how CBD has caught upon people. CBD contains THC like Marijuana but in lower quantities. Marijuana has intoxicating effects on the user which CBD does not have. The main concern is the usage of THC in it that might pose risks while breastfeeding and pregnancy.
In the meantime, when states are making marijuana legal, products containing THC also is increasing in popularity. Many people believe that both marijuana and CBD have their health benefits. People who vouch by CBD have claimed that they have found relief from conditions like depression, anxiety, acne, insomnia, and even inflammation because CBD is anti-inflammatory.
Known benefits were also experienced by people suffering from epilepsy and cancer. Although cancer was not cured yet it relaxed the very many disturbing symptoms of the disease. People often confuse with marijuana with CBD because it can be extracted by both hemp plants and marijuana. But the CBD found on upper portions of the plant has less than 0.3% THC levels which are the legally acceptable limit.
But there are two sides to every coin, and marijuana has its side-effects too. Much is now known about them especially women who are pregnant or are breastfeeding. Dr. Jennifer Conti who is an OB-GYN at the Stanford Health care spoke to Healthline that nothing does have to be in trend, but when something lacks the scientific backing and research data, it is medically right to proceed further with caution.
Some of the major risks are
FDA believes that are apparent risks associated with using marijuana while pregnant or lactating. FDA had earlier warned that THC can reach the brains of the fetus through the bloodstream of the mother. It can cause damages to the brain development of the child when he or she is born. The other risks include low birth weight, premature birth or even stillbirth.
While breastfeeding, if the THC goes into the baby’s system through mother’s milk, the child’s brain development will surely get affected in addition to poor cognitive abilities. The more the THC taken, the greater is the loss. When it comes to CBD and its ill-effects, not much literature is yet available in the market to determine its exact ill-effects. But only with time, the risks can be known and it does not imply that there aren’t any risks at all.
But in studies conducted on animals, it was revealed that the male fetuses suffered a hampered reproductive system. FDA also fears that CBD products may, after all, be contaminated with a lot of harmful chemicals like pesticides, fungus, and bacteria which in turn will harm the baby.
Dr. Jennifer wants users to be safe until more is known about them. She tells women to play safe and use alternative therapies like serotonin reuptake inhibitors (SSRIs) to treat pain and depression instead of using CBD.
CBD market is predominately unregulated. FDA approval is not necessarily required for it and many products are already available on racks. The nature, usage and the ingredients inside the product is still a big mystery and needs to be unraveled. People and FDA are unaware yet of the possible side effects barring some studies that have shown side-effects like toxicity and sleepiness especially when they interact with other drugs.
Many research scientists are curious to know how CBD can help and what its potentials are and that is why they believe that research is needed. Even to prove that the use of CBD, while pregnant or breastfeeding has ill-effects, cannot be proven by FDA as there is a lack of any human evidence for the same.
There have been studies conducted on animals, but the results cannot be applied to humans chiefly because of the different physiological order. Until there is more in hand in terms of data and rules, it is advisable for women to refrain from such things that might cause harm.
The FDA had released warning early this month clearly warning people against the use of marijuana or CBD containing THC levels especially when one is breastfeeding or is pregnant. The potential risks are far too risky than to take the risk of having it mixed in the bloodstream affecting the growth of the fetus.
Meta: FDA issues warning to lactating and pregnant women about the potential damages of using CBD and marijuana during this stage.
American Google Search for CBD Surpass Meditation, Exercise and Acupuncture, Study Suggests
People are more curious about cannabidiol or CBD than other trends in health like exercise, apple cider vinegar, acupuncture, and veganism, as stated in a new study.
CBD has grown increasingly more popular that people have been observed to Google search it as much as e-cigarettes and yoga.
According to a paper recently published in the Journal of the American Medical Association, proponents analyzed data on Google searches from January of 200 until April of this year. Results showed that cannabidiol and CBD was a dormant keyword before 2014. Searches continued to spike following that year.
Details of the review
In 2017, keyword searches relating to CBD grew by 126% in comparison to the previous year. It then increased to 160% high in 2018 and is again expected to grow by 117% this year based on the forecasted volumes and observed trends last year.
Authors stated in the paper that the national interest for CBD in the US is accelerating as seen in the substantial increase of keyword searches. In the longitudinal cross-sectional study, Google is the search engine of focus and reflects CBD’s curiosity rather than CBD use.
They also attribute the trend to various health-related behaviors like e-cigarette use. They further suggested that CBD investigation should be prioritized as a public health matter to keep up with consumer demands.
The researches also encourage further studies on the use of CBD and their purpose for taking it. They also call for the development of safety standards for CBD products because a number of such items are adulterated or mislabeled. They suggest standardized marketing practices to further develop consumer trust in evidence-based medicine.
Key statistics from the study
Americans searched for cannabidiol around 6.4M times in April of this year alone. The states with the most CBD searches for 2019 include New Hampshire, Colorado, Oregon, Tennessee, and Wisconsin.
CBD searches in April 2019 surpassed Google inquiries for meditation by 3.38, apple cider vinegar by 5.17, and acupuncture by 7.49. Also, CBD eclipsed trends like veganism by 1.12, marijuana by 1.13, the exercise by 1.59 and vaccination by 1.63.
The paper also showed how CBD ties up with searches for e-cigarettes (factor by 0.96) and yoga (factor by 1.59) and is also searched for nearly half that of dieting (0.51).
Based on a survey released by Gallup in August, usage of the said compound has increased and indicated that 1 in 7 Americans are taking CBD and CBD-infused products.
Cannabidiol or CBD is a derived compound from the cannabis plant species Cannabis sativa L. It’s every bit as controversial as marijuana, it’s cousin derivative, but not for the negative reasons. CBD is believed to alleviate and/or cure various health conditions. The advantage is that it does not have any psychoactive effects like that of marijuana.
CBD is federally legal across all of the US but is still subject to various state laws related to the matter. CBD and CBD-containing products can be purchased, sold and used provided that it does not exceed a THC limit of 0.3%.
Beware CBD Users: Failing Drug Test Without THC Consumption is Possible
Rose Maxey, a Fresno resident, relayed to ABC30 how her use of CBD pills for her chronic back pain led her to fail a drug test for her temp job.
She told the news outlet how THC was found in her urine despite not taking drugs or even smoking a cigarette. At 61, it’s also the first time she flunked a routine drug test.
CBD and its link to THC
CBD is a derived compound from the cannabis plant that is popular for its alleged therapeutic properties. THC, on the other hand, is a psychoactive component of the same plant species.
According to federal law, CBD is legal as long as it is derived from the hemp plant and contains 0.3% of THC and below. Marijuana, also a cannabis product, has 5% or more THC.
CBD gets embroiled in drug test failures is because regular urine testing cannot distinguish CBD from THC.
Dr. Alan Barbour, a forensic toxicologist, stated that screening for THC might mistake CBD as the psychoactive substance. Professional blood testing might be a better indicator of whether a person consumed THC.
Barbour was the first one to launch a marijuana screening facility in the Valley.
Another reason for CBD causing a false positive drug test result is that the CBD industry is mostly unregulated, or even self-regulated.
Scott John Van Horn from CBD Center said that most CBD products do not come from government-sanctioned programs, making regulations a bit slow to keep up with the trend.
Central Valley CBD Pure’s Steve Penn stated that CBD users are responsible for what they take. They can’t blame anyone when they haven’t paid attention to the product, read the label, or asked their questions before using it.
CBD is considered legal, but there are still several gray areas existing in the industry.
The Food and Drug Administration (FDA) is yet to release official guidelines for CBD and hasn’t reviewed or evaluated CBD products for safety or effectiveness in treating diseases.
In a letter penned by lawmakers, including Senate Majority Leader Mitch McConnell, the FDA is urged to finalize rules and regulations for cannabidiol, which includes official testing to ensure that the THC level of a product is legal.
Various CBD businesses are also pushing for regulations, seeing as some owners meet run-ins with the law due to uncertainty of whether their products are lawful to sell. Specific issues like which parts of the hemp plant are legal to have gotten CBD shop proprietor in trouble.
Regulation is a good thing, so consumers and businesses have something to fall back to, adds Tower Health Food’s, Shannon Johnson. It’s especially relevant now that people who get tested for drugs suffer from false-positive results after taking CBD.
As for Rose Maxey, she insisted on taking cannabidiol since it works for her. However, she plans on cutting back if she ever gets another mandatory drug screening.
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