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Synthesized CBD May Help Treat Seizures



Seizures CBD

Although CBD, by itself, doesn’t have any psychedelic properties, the plants that it’s derived from does contain another form of intoxicating substances (THC for example). But that does not stop its persecutors from viewing this substance as “evil”. This discourages people who can benefit from CBD from seeking aid. Luckily, to counter this social taboo, there are synthetic forms of CBD that can work just as well.

Synthetic CBD

A recently published paper discusses this synthetic CBD. The chemical build of this substance is similar to the CBD that can be found in the cannabis plant. The synthesized cannabidiol has the scientific name of 8,9 Dihydrocannabidiol or H2CBD. Herbal CBD has its own share of disadvantages, compared to this new form of CBD, which makes this development an invaluable addition to the medical community.

First of all, herbal CBD is considered a controlled substance in many countries, thus inhibiting its use and distribution in many places. Synthesized CBD, however, does not face such negativity and can benefit a lot of people. Second, cannabis plant requires a lot of effort to farm and produce with constant maintenance and monitoring for months until they can be used to extract CBD. Furthermore, extracting the components and isolating the CBD itself is a tedious process.

However, H2CBD can be processed and synthesized in the lab using cheap chemicals that do not even require cannabis plants. They can be extracted and purified far more easily than the herbal CBD. Above that, drug producers can convert CBD into THC which is impossible with H2CBD.

A New Cure for Seizures

Cannabis has been used as a treatment for seizures for over a hundred years. So, it’s no surprise that even H2CBD has been attempted to be used as a cure for epileptic seizures. This new form of CBD has been tested on rats and have been found to be effective at suppressing epileptic seizures and provide relief. Scientists claim that they are going to run further animal tests before moving on to do clinical trials with this new form of CBD.

It hasn’t even been about 20 years since Scientists discovered that the Endocannabinoid System in the human body uses and reacts to cannabidiol and other substances in Cannabis to suppress the epileptic symptoms. Among these substances, THC and Cannabidiol are the two most powerful substances that do that. Although Cannabidiol is less effective than THC itself, its lack of psychedelic properties makes it a better choice for a cure, even for dogs.

Although the FDA approves of some forms of the herbal extract of cannabidiol as a means of treating seizures, their stance on the chemical substitute still remains to be seen. Above that, CBD is supposed to be used as a last resort for the treatment of some forms of refractory epileptic seizures as well as for anxiety.

With that said, around 3.4 million people are diagnosed with epilepsy in the US alone. According to the 2015 survey, among these, 470,000 are just children. So, the arrival of a new, cheaper medical alternative to CBD for their treatment is good news for the whole world.

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Hepatotoxin and Liver Damage – The Side Effects of CBD



CBD Side Effects Liver Damage

In physics, the formula of Momentum is Mass multiplied by Velocity. If that’s the case, then the CBD Bandwagon is gaining momentum, day by day.  The rate at which people and nations are accepting its use and production propagates its velocity. The increasing popularity of the substance is leading more and more people and organizations to get on the CBD Bandwagon, increasing its support and mass. Combined, its slowly turning into an unstoppable force.

But what happens when that unstoppable force meets an immovable object? Nerdy physics and sagacious philosophies aside, its side-effects might just be the immovable object that it collides into. According to the Molecules Journal, Volume 24, Issue 9, CBD is not as harmless as its supporters make it out to be.

The Role of CBD in Medicine

But why do people use CBD in the first place? For starters, it’s the substance found in Cannabis that is non-addictive (THC is the addictive part). So, naturally, the belief that goes with that, makes it a lot less harmful than THC. Given its pain relieving and sleep-inducing properties, it provides the same effects with a lot fewer side-effects than its alternatives (like opium).

When we say “a lot less harmful” we mean “a lot less harmful” and not “harmless”, as most of its supporters are believing it to be. Sure, it has its own benefits not only with its restorative properties but also in its effectiveness in suppressing epileptic symptoms, as evidenced by the studies conducted by Devinsky and Sanjay Gupta. But that does not warrant a full green light for this product’s side-effects.

Cannabidiol’s Side Effects on the Liver

According to the study conducted for the Journal, the effects on the hepatotoxicity on 8-week-old mice have been observed. All the specimens were males and different groups have been tested with different dosage of CBD. These dosages were calculated and administered according to the mice’s bodies, meaning, the dosage administered for human subjects were scaled down to match the requirements of a mouse’s body.

The results showed a stunning 75% of the test subjects with a dosage above 615 mg/KG, showing signs of damaged liver, including increased bilirubin, LBW Ratios, AST and ALTs in just one day. The CBD definitely displayed some hepatotoxic behavior, but the Journal concludes it to be of a cholestatic nature, with a hint of “maybe”. While there have been a “maybe” on its nature, there was no doubt about its hepatotoxicity.

The Proper Use of CBD

With all the research going on, and the benefits of CBD being so clear, it’s hard to just stop right here and move on without using it. Now that the benefits of CBD have been widely accepted by the medical community, it’s time to look into its proper use with calculated doses. Because, to be honest, no modern medication comes without its own sets of side-effects anyway.

But if the studies were any indication of how CBD is going to react with human bodies, then we should remain well under the daily limit of 20 mg/KG dosage. In all honesty, even if we maintained that limit, we’d still be well below the 615 mg/KG dosage that resulted in the liver damage of the mouse subjects. That obviously doesn’t mean that 20 mg/KG is safe either since 615 mg/KG caused the damage in a day and lower doses might cause the same damage through long-term use. But if CBD is taken with proper care and in the right amounts, you could reap its benefits without its negative effects.

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NFL & NFL Players Association Team Up For Studying Pain Management Using Marijuana In A Legal Way




The NFL Players Association and NFL have decided to study further on the potential of marijuana for being used to ease out the pain experienced by players due to sports injuries. This can serve as a paradigm change in the approach of the league which has also been hinted at by several players till date.

Committee Formation

Two brand new medical committees shall be formed by the union and the league which will help in solving various medical issues. The review of policies and practices of the teams shall also be undertaken for prescribing medication to the players. Various controversial topics will be tackled by the committees of NFLPA and NFL. Different players had previously expressed frustration over imposing bans and other stringent punishment on players who have been tested positive for marijuana.

Allen Sills, the league’s chief medical officer, revealed in a phone interview that, “I think it’s a proud day for the NFL and the NFLPA to come together on these issues in a very public way.” He further added that “I think it demonstrates the spirit of cooperation we have around our health and safety issues. … Both of these committees are about providing the best health care we can to players.”

Roadmap Ahead

Both union and league officials revealed that the committees will start with their work soon enough. However major policy changes if any shall be made using traditional channels of the collective bargaining process in between NFLPA and NFL or through annual negotiations held jointly over administered drug policies.

Amongst the two committees, one shall specialize in pain management whereas the other will specialize in mental health and wellness. Apart from studying the possibilities of marijuana, the pain management committee will also study different strategies which can assist the players. Sills also revealed that “We’re asking our pain management committee to bring us any and all suggestions. We’ll look at marijuana.”

Marijuana Ban

Marijuana, as we all know, stands out as the top contender of the league’s banned substance. However former players hold the opinion that marijuana can help them tackle problems which arise from playing violent sports. It is thus desirable for the NFL to relax its standards for the betterment of its players.

Expert Speak

Eugene Monroe is an offensive lineman of Baltimore Ravens who had earlier called on the league for showing a green signal to the usage of medical marijuana. Monroe revealed in 2017, “This pain is never going away.” He further added that “My body is damaged. I have to manage it somehow. Managing it with pills was slowly killing me. Now I’m able to function and be extremely efficient by figuring out how to use different formulations of cannabis.”

Roger Goodell the NFL Commissioner held the view that the league should allow players the usage of marijuana for managing pain provided they can support the same with valid scientific and medical claims. A pain management specialist shall be appointed by each NFL team within the 2019 season who will work in close proximity with the league, players, and union.

Effective Pain Management Tool

The NFL had revealed in July 2017 that it shall work in collaboration with the NFLPA for studying potential marijuana usage to ward off painful sensations. The union was at that time studying the issue along with its very own pain management committee and did not respond to the same immediately.

NFLPA’s executive director DeMaurice Smith revealed in a January 2017 interview that the union was preparing itself for undertaking a “less punitive” approach of dealing with the usage of recreational marijuana by the players. The union and league have started discussions on bringing about a collective bargaining agreement and their present labor deal shall run through the 2020 season.

Thus, any alterations to the sports marijuana policy shall be considered for CBD negotiations. Alternatively, they will come through the yearly deliberations of both the sides about their drug policies. The committee shall study pain management and receive recommendations for a prescription drug monitoring program which shall “monitor all prescriptions issued to NFL players by club physicians and unaffiliated physicians.”

Bottom Line

Sills ended the interview saying that “This concept of prescription monitoring is happening throughout medicine, not just in the NFL.” A grievance was filed in May 2017 by NFLPA which accused both the teams and league of violating the terms of CBA which governed safety and health issues. The main reason behind this grievance is allegations against team members of recklessly using painkillers like opioids to ward off pain.

A person possessing knowledge about NFLPA’s viewpoint in regards to the new medical committee formation revealed that “One of the outcomes of that [grievance] was to create something jointly that will generate far more trust. I think this will lead to far more transparency. It will be a process that we will have to work to perfect. We’re both serious about it.”

Each team will be mandated by the union and the league for having a clinician who will spend 8-12 hours weekly at the practice facility of the respective teams. According to Sills, “This is a person who’s coordinating a network of providers.”

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Small Scale Tests Show That CBD Can Help Manage Opioid Addiction



Opioid Addiction CBD

Opioids, while used as a prescription painkiller, has been proven to cause addiction among its users. While the use of these substances cannot be avoided in some circumstances, the chemical dependency it creates is a cause for major concerns amongst the medical community. Fortunately, a recent study out yesterday shows some promising results by using CBD as a substitute to contain withdrawals. When combined with controlled doses, CBD can be used to reduce cravings for Opioids and calm the nerves of the dependants.

According to a professor of Psychiatry, Neuroscience, and Pharmacology at Icahn School of Medicine, Yasmin Hurd, this is a remarkable breakthrough. This is because the successful production of a substitute non-opioid medication would add enormous benefits to the medical world. This is basically because CBD (cannabidiol) contained in Cannabis isn’t the stimulant that causes euphoria, and thus provides more benefits without the side-effects. While it’s already being used as a prescription medicine with several other rumored benefits, the results of the study show clear signs that at least one of those rumors might have some substance behind it.

The test was conducted among 42 participants of either gender. All of these participants had already been suffering from opioid disorders, namely, heroin, but we’re currently off the drugs. Half of the subjects were given only a placebo pill making them a control group, while the others were treated with pills containing CBD. The second group reported fewer withdrawal symptoms and anxiety and their vitals evidenced similar results. Their heart-rate was slower and the cortisol levels in their saliva were lower.

This result, while still remains to be tested on a larger range of subjects and people who are currently addicted to and using opioids, still carries some big implications. If CBD can indeed be a substitute for Opioids as a painkiller or at least contain their addictive characteristics, this can be a major breakthrough in medicine. More and more people can have access to the medication and pain-killers they need without having to worry about the side-effects they can bring.

There is already medicine out there that can be used to manage Opioid withdrawal symptoms, like buprenorphine and methadone, these are not easily accessible. Besides, most of the rehabilitation centers don’t even offer these medicines as a solution to the withdrawal symptoms. With CBD being a natural substance and being relatively easier to obtain, they can be used by a lot more patients suffering from Opioid addiction than before.

More and more people are now coming to recognize the benefits of using CBD. Citizens of Idaho are voting towards the legalization of CBD as a medicinal alternative to Opioids with the Church’s support. Similarly, a certain ethnocentric group from Chicago is pushing forward for this as well with Texas giving their green light for the hemp legalization bill. With this recent development out in the open, we can expect to see a greater range of use and advancements in medicine on the horizon through the use of CBD as a substitute.

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